In the 311th episode of Semantic Mastery's weekly Hump Day Hangouts, one participant asked if it is safe to run URLs already indexed through an indexer.
The exact question was:
Hey guys, looking to get myself a subscription to an indexing service. Is it safe to run urls already indexed through an indexer. I have spreadsheets created months ago with links I manually built to a money site and pinged all the urls back then. Some indexed naturally but the others havent. Would it be safe to run all those links through the indexer or could I risk deindexing them completely. These are quality links to the money site not tiered web2s.